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目的 探讨弥漫性棘慢波综合 (GSWD)及失神发作 (AS)在儿童良性癫伴中央 中颞棘波发放 (BECCT)患者中的发生情况 ,分析BECCT与AS间的可能的相互联系。方法 回顾性分析5年来诊断为BECCT的 5 2 4例患者的临床及录像脑电图 (VEEG)资料。我们对GSWD的入选标准为 :在正常背景活动中 ,突然发生和中止、频率 2 .5～ 3.5Hz、双侧对称或大致对称的棘慢波综合 (棘波数≤ 2 )。结果 在 5 2 4例BECCT患者中 ,GSWD及AS的发生率分别为 5 3%和 2 0 %。绝大多数合并有AS的BECCT患者对单药治疗效果较好。结论 BECCT和AS可发生在同一例患者中 ,提示这两种常见的癫综合征之间可能存在某些类似的发病机制。
Objective To investigate the incidence of diffuse spike-wave synthesis (GSWD) and absence of seizures (AS) in children with benign epilepsy with central temporal spike wave dissemination (BECCT) and to analyze the possible interrelationship between BECCT and AS. Methods The clinical and video-record EEG data of 524 patients diagnosed as BECCT in 5 years were retrospectively analyzed. Our inclusion criteria for GSWD are sudden and discontinuous events of normal background activity at frequencies of 2.5-3.5 Hz, bilaterally symmetric or approximately symmetrical spike-and-wave synthesis (spikes ≤ 2). Results Among 544 patients with BECCT, the incidences of GSWD and AS were 53% and 20% respectively. The vast majority of patients with BECCT complicated by AS have a better response to monotherapy. Conclusions BECCT and AS may occur in the same patient, suggesting that some similar pathogenesis may exist between these two common epilepsy syndromes.