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我校华山医院药剂科研制的复方盐酸去氧肾上腺素滴眼剂(简称滴眼剂),治疗眼部红肿,效果甚佳。处方中除含有盐酸去氧肾上腺素(PPH)外,还含有醋酸氢化可的松(HCA)、局麻药、抗生素及抗氧剂、防腐剂等多种成分。HCA及PPH的定量方法很多,例如常用紫外分光光度法、四氮唑法、异烟肼法测定HCA,用紫外分光光度法、溴量法、N-溴代琥珀酰亚胺法测定PPH,但是它们在本类复方制剂中的定量方法尚未见报道。由于复方制剂中其他成分的干扰,上述方法均不能直接使用。经过试验证明:用盐酸苯肼法测HCA,用4-氨基安替比林法测PPH,不经分离直接测定,制剂中其他成分没有干扰。
Huashan Hospital, our school developed pharmaceutical compound phenylephrine hydrochloride eye drops (referred to as eye drops), the treatment of eye swelling, the effect is very good. In addition to the prescription contains phenylephrine hydrochloride (PPH), but also contains hydrocortisone acetate (HCA), local anesthetics, antibiotics and antioxidants, preservatives and other ingredients. HCA and PPH are many quantitative methods, such as commonly used UV spectrophotometry, tetrazolium method, isoniazid method for the determination of HCA, UV spectrophotometry, bromine method, N-bromosuccinimide method for the determination of PPH, but Their quantitative methods in this type of compound have not been reported. Due to the interference of other components in the compound preparation, the above methods can not be used directly. After the test proved: hydrochloric acid phenylhydrazine method for the determination of HCA, 4-amino antipyrine method for the determination of PPH, without direct determination of the separation, the preparation of the other components without interference.