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目的 :不经分离直接测定茶碱缓释片含量。方法 :二阶导数光谱法。结果 :茶碱在 2 .5～ 12 .5 μg ml浓度范围内线性关系良好 ,r =0 .9998平均回收率 10 0 .0 8% ,RSD 1.84(n =5 ) ,测得茶碱含量符合中国药典规定。结论 :该方法测定茶碱缓释片含量准确、快捷 ,与中国药典该项下化学滴定法测定结果基本一致。
OBJECTIVE: To determine the content of theophylline sustained-release tablets without isolation. Methods: Second-order derivative spectroscopy. RESULTS: Theophylline had a good linearity in the range of 2.5 ~ 12.5 μg ml with an average recovery of 10.08% and RSD 1.84 (n = 5) Chinese Pharmacopoeia regulations. Conclusion: The method for the determination of theophylline sustained-release tablets content is accurate and fast, and the Chinese Pharmacopoeia under the chemical titration results are basically the same.