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目的：讨论儿童骨嗜酸性肉芽肿的影像学特点及临床表现，提高对骨嗜酸性肉芽肿的诊断与治疗水平。方法回顾性分析2003年至2013年我们收治的34例儿童骨嗜酸性肉芽肿患儿的影像学、临床、病理资料及随访结果，所有病例均经病理检查证实为嗜酸性肉芽肿，患儿平均年龄6．3岁。结果全部病例均获随访，随访时间6个月至10年，平均随访6年8个月，其中孤立性病变21例，多骨病变5例，多系统病变8例，免疫组化检查结果显示 CD1 a、S －100 protein 和 CD68阳性率分别为100％（34／34）、94．1％（32／34）和85．2％（29／34）；保守治疗18例，手术治疗16例，其中复发1例，予加强化疗后治愈，所有患儿在最后一次随访时均获得良好的结果。结论儿童骨嗜酸性肉芽肿的临床及影像学表现多样，容易与其它病变混淆而致误诊，综合临床及影像学检查资料可以提高诊断准确率，但确诊需要病理学检查，治疗多选择保守治疗。“,”Objetive To investigate the clinical characteristics and imaging features of eosinophilic granuloma of bone in children and improve the diagnosis. Methods 34 cases of eosinophilic granuloma of bone in children from 2003 to 201 3 were admitted,their clinical characteristics,radiographs,pathological data, outcomes and prognos were reviewed,all cases had bbeen confirmed eosinophilic granuloma by pathological da-ta.Results The time of follow-up ranged from 6 months to 1 0 years(6.8 years in average).23 boys and 1 1 girls with an average age of 6.3 years.21 cases had a solitary bone lesion,5 cases had multiple bone lesions and 8 cases involved multi-systems.Immunohistochemistry showed that CD1 a,S -1 00 protein and CD68 positive were 1 00%(34 /34),94.1 % (32 /34)and 85.2%(29 /34);1 8 patients received conservative treatment,1 6 patients had surgical rtreatment,one case relapsed,had been cured after strengthened chemotherapy.All patients were alive and well at the time of the most recent follow-up. Conclusions The clinical behavior and imaging feature of eosinophilic granuloma of bone is often various;however,comprehensive analysis of examination can get comparatively accurate diagnosis and reduce the rate of misdiagnosis.The final diagnosis requires a biopsy. Most patients can choose conservative treatment.