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本文报告慢性肾炎患者白细胞介素－６（ＩＬ－６）的水平（７例）及Ｔ细胞亚群的变化（１９例）．Ｔ细胞亚群分析用ＣＤ３、ＣＤ４、ＣＤ８、Ｔγδ等单克隆抗体进行间接免疫荧光法测定；ＩＬ－６用ＩＬ－６依赖细胞Ｂ９细胞增殖的生物学测定法。７例患者ＩＬ－６的活性均显著增高（Ｐ＜０．０１）。１９例患者的Ｔ细胞亚群有异常改变：ＣＤ_４~＋细胞明显下降，ＣＤ_８~＋细胞在多数病例内增加，但可因慢性肾炎的类型而不同，ＣＤ_４~＋／ＣＤ_８~＋比值降低。１７例患者Ｔγδ细胞显著高于正常对照组。根据上述变化，本文对慢性肾炎发病的有关机理作了初步探讨。
This article reports the levels of interleukin-6 (IL-6) (7 patients) and T-cell subsets (19 patients) in patients with chronic nephritis. T cell subsets were analyzed by indirect immunofluorescence using monoclonal antibodies such as CD3, CD4, CD8, and Tγδ; and biological assays for the proliferation of IL-6 using IL-6-dependent B9 cells. The activity of IL-6 in all 7 patients was significantly increased (P <0.01). T cell subsets in 19 patients had abnormal changes: CD_4 ~ + cells decreased significantly, while CD_8 ~ + cells increased in most cases, but the ratio of CD_4 ~ + / CD_8 ~ + decreased due to the type of chronic nephritis. 17 cases of Tγδ cells was significantly higher than the normal control group. Based on the above changes, this paper made a preliminary study on the pathogenesis of chronic nephritis.