目的　探讨IL 10、IL 12、sIL 2R、TNF在慢性乙型肝炎发病中的作用 ,观察IFN抗病毒治疗对于上述因子水平的影响。方法　ELISA法检测 14例正常人及 30例慢性肝炎患者 (包括IFN治疗前后 )血清中上述细胞因子水平。结果　慢性肝炎患者血清中上述细胞因子水平显著高于正常对照组 (P <0 .0 5 ) ,且其值与ALT显著正相关 ;经IFN治疗后上述因子水平均明显降低 ,抗病毒无效组治疗前血清中sIL 2R、IL 10水平明显高于有效组 (P <0 .0 5 )。结论　上述因子共同参与了慢性乙型肝炎的发病 ,并可用于评价IFN对于机体免疫状态的影响 ;且sIL 2R、IL 10对预测抗病毒疗效有重要意义。 Objective To investigate the role of IL 10, IL 12, sIL 2R and TNF in the pathogenesis of chronic hepatitis B. To investigate the effect of IFN antiviral therapy on these factors. Methods Serum levels of these cytokines were measured by ELISA in 14 normal subjects and 30 chronic hepatitis patients (including before and after IFN treatment). Results Serum levels of these cytokines in patients with chronic hepatitis were significantly higher than those in normal controls (P <0.05), and their values ​​were significantly and positively correlated with ALT. The levels of these factors were significantly decreased after IFN treatment, The levels of sIL 2R and IL 10 in pre-serum were significantly higher than those in the effective group (P <0.05). Conclusions These factors are involved in the pathogenesis of chronic hepatitis B and can be used to evaluate the effect of IFN on immune status. And sIL 2R and IL 10 are important for predicting antiviral efficacy.