癫痫的产生是神经元兴奋性和抑制性通路失衡的结果。神经元电位的产生与离子通道密切相关,离子通道功能障碍可直接导致神经元兴奋,引起癫痫发作[1]。有研究发现40%的特发性癫痫与遗传相关[2],迄今已发现14个基因突变,其中大多编码离子通道,包括电压门控通道(Na+、Ca2+、K+、Cl-)和配体门控通道(GABA受体、烟碱乙酰胆碱受 The production of epilepsy is the result of an imbalance in the excitability and inhibitory pathways of neurons. The generation of neuron potential is closely related to the ion channel, and ion channel dysfunction can directly lead to the excitement of neurons and cause seizures [1]. Studies have found that 40% of idiopathic epilepsy and genetic correlation [2], so far found 14 mutations, most of which encode ion channels, including voltage-gated channels (Na +, Ca2 +, K +, Cl-) Control channels (GABA receptor, nicotinic acetylcholine receptor