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目的 :探讨血浆环核苷酸在妊高征中的变化以及作用。方法 :采用竞争性蛋白结合分析的方法及其放射免疫方法测定 2 5例重度妊高征和 2 7例正常妊娠晚期妇女 (对照组 )血浆中环磷酸腺苷 (c AMP)和环磷酸鸟苷 (c GMP)的含量。结果 :妊高征患者血浆 c AMP和 c GMP的浓度远远高于正常对照组 ,并且妊高征产后组明显低于产前组。产前 c AMP与产后平均动脉压 (MAP)之间呈明显的负相关。结论 :c AMP和 c GMP在妊高征中表现出相互协同的作用 ,共同拮抗细胞内 Ca2 +升高引发的血管收缩
Objective: To investigate the changes and effects of plasma cyclic nucleotide in pregnancy induced hypertension. Methods: The levels of cAMP and cGMP in 25 patients with severe PIH and 27 normal pregnant women (control group) were measured by competitive protein binding assay and radioimmunoassay c GMP) content. Results: Plasma cAMP and c GMP concentrations in patients with PIH were much higher than those in the normal control group, and PIH group was significantly lower than that in the prenatal group. Prenatal c AMP and postpartum mean arterial pressure (MAP) showed a significant negative correlation. CONCLUSION: c AMP and c GMP show synergistic effects in PIH and antagonize the vasoconstriction induced by elevated intracellular Ca2 +