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目的 :观察淫羊藿提取液对庆大霉素致大鼠急性肾毒性的作用。方法 :测定大鼠血肌酐、尿素氮的浓度及肾皮质脂质过氧化终产物丙二醛和谷胱甘肽的含量 ,分析淫羊藿提取液对大鼠肾损伤的有效作用。结果 :淫羊藿提取液可降低血肌酐和尿素氮水平的升高 ,抑制肾皮质脂质过氧化物的产生及减轻谷胱甘肽的耗竭。结论 :淫羊藿提取液对庆大霉素所致肾损伤具保护作用 ,其机制可能与抗脂质过氧化作用有关
Objective: To observe the effect of Epimedium extract on acute nephrotoxicity induced by gentamicin in rats. Methods : The concentration of serum creatinine and urea nitrogen in rats and the content of malondialdehyde and glutathione in the renal cortex lipid peroxidation end product were measured. The effect of Epimedium brevicornum extract on renal injury in rats was analyzed. Results: Epimedium extract can reduce the increase of serum creatinine and urea nitrogen, inhibit the production of lipid peroxide in renal cortex and reduce the depletion of glutathione. Conclusion : Epimedium extract has a protective effect on gentamicin-induced renal damage, and its mechanism may be related to anti-lipid peroxidation