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目的:研究布洛芬不同时辰给药对大鼠体温降低作用及血药浓度的昼夜节律变化规律。方法:采用随机区组实验设计,60只大鼠分别在不同时间(2:00、6:00、10:00、14:00、18:00、22:00)单次灌胃给予布洛芬颗粒50mg.kg-1,另取10只为空白对照,观察大鼠体温和血药浓度的昼夜节律变化规律,以时间图和余弦法进行分析。结果:大鼠正常体温及用药后体温均呈现明显的昼夜节律变化,峰值相位及振幅无显著改变,仅均值下降;最佳拟合曲线分别为Yti=38.7+0.52Cos(15°×ti—86.80°)和Yti=37.8+0.55Cos(15°×ti—117°)。大鼠在不同时辰给药血药浓度亦呈现明显的昼夜节律变化,明期血药浓度高于暗期,最佳拟合曲线Yti=41.95+5.30Cos(15°×ti—272.83°)。结论:大鼠在不同时辰给予布洛芬,体温和血药浓度均存在昼夜节律的差异。
OBJECTIVE: To study the circadian rhythm of different effects of ibuprofen on the hypothermia and plasma concentration in rats. Methods: Randomized block design was adopted. Sixty rats were orally administered with ibuprofen at different times (2: 00,6: 00,10: 00,14: 00,18: 00,22: 00) Granules 50mg.kg-1, and the other 10 as a blank control, observed rat body temperature and plasma concentration of circadian rhythm changes in time and cosine analysis. RESULTS: The normal body temperature and body temperature of rats showed obvious circadian rhythms, the peak phase and amplitude had no significant change, only the mean decreased. The best fitting curves were Yti = 38.7 + 0.52Cos (15 ° × ti-86.80 °) and Yti = 37.8 + 0.55Cos (15 ° × ti-117 °). The plasma concentration of rats administered at different time also showed significant changes in circadian rhythm. The plasma concentration in the period was higher than that in the dark phase. The best fit curve was Yti = 41.95 + 5.30Cos (15 ° × ti-272.83 °). CONCLUSION: Ibuprofen was given to rats at different time points. There was a difference in circadian rhythm between body temperature and plasma concentration.