中科院大连化物所胡向平研究员带领研究团队在铜催化不对称炔丙基转化研究中取得新进展,通过运用一种脱硅活化的新策略,成功实现了Cu-催化的炔丙醇酯与β-萘酚及富电子苯酚间的不对称[3+2]环加成反应,相关研究结果以通讯形式发表在最新一期的《德国应用化学》上。在炔丙基转化反应中,有效形成亚丙二烯基铜活性中间体是实现反应的关键。针对传统的由端基炔丙基化合物形成 Researcher Hu Xiangping, led by the CAS Dalian Institute of Chemical Physics, led the research team to make new progress in copper-catalyzed asymmetric propargyl conversion. By adopting a new strategy of desiliconization activation, Cu-catalyzed propargyl propionate and β- Asymmetric [3 + 2] cycloaddition reaction between naphthol and electron-rich phenol. Relevant research results were published in the latest issue of German Applied Chemistry by way of communication. In the propargyl conversion reaction, the effective formation of propylene-based copper intermediates is the key to achieve the reaction. For the traditional terminal propargyl compounds formed