促红细胞生成素(EPO)是一种多效性细胞因子和糖蛋白样激素,临床上主要用于治疗由慢性肾脏疾病导致的贫血。除了其在造血方面的功能外,近年来,EPO作为一种对许多非造血组织有保护功能的细胞因子而引起广泛关注。有研究表明,高剂量的EPO介导了对小鼠体质量、脂肪量以及葡萄糖耐受性的影响,因此扩展了其对脂肪和葡萄糖代谢的多效性作用。但是,到目前为止,尚不明确EPO是否能降低食物的摄入,增加身体的活动以及增加红细胞的比容。本实验旨在研 Erythropoietin (EPO) is a pleiotropic cytokine and glycoprotein-like hormone that is clinically mainly used to treat anemia caused by chronic kidney disease. In addition to its function in hematopoiesis, EPO has drawn much attention as a cytokine that has protective function on many non-hematopoietic tissues in recent years. Studies have shown that high doses of EPO mediate effects on body weight, fat mass, and glucose tolerance in mice, thus extending their pleiotropic effect on fat and glucose metabolism. However, so far, it is unclear whether EPO can reduce food intake, increase physical activity and increase the specific volume of red blood cells. This experiment aims to research