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淀粉样变并不少见。其患病率虽无确切统计,但有报告在住院病人中的发生率为0.09～8%。除系多种疾病的继发表现外,近年来注意到它与老年性心肌病、早老性痴呆(prese-nile dementia)等病的发病机制有关,值得重视。本文叙述国外在淀粉样变的若干进展。病理和生化病理淀粉样变物是一种无定形、嗜酸性、玻璃样透明的物质。用刚果红(congo-red)染色后在偏振显微镜(polarizing microscope)下,显示特有的绿色双折射(green birefringen-ce),此为检查淀粉样变物质最有效的方法。天狼星红(sirius red)染色也有高度的敏感性和特异性。淀粉样变物质存在于细胞外间隙结缔组织中,常沉积在血管周围,可侵犯心、肾、消化道、胆囊、胰腺、肝、支气管、肺、神经系统
Amyloidosis is not uncommon. Although its prevalence is not exact statistics, but there are reports of hospitalized patients in the rate of 0.09 to 8%. In addition to the secondary manifestations of various diseases, it is worth noting in recent years that it is associated with the pathogenesis of diseases such as senile cardiomyopathy and prese-nile dementia. This article describes some of the advances in amyloidosis abroad. Pathological and biochemical pathology Amyloidosis is an amorphous, eosinophilic, glassy substance. Under the polarizing microscope after staining with congo-red, green birefringen-ce has been shown to be the most effective method for detecting amyloidosis. Sirius red staining is also highly sensitive and specific. Amyloidosis exists in the extracellular space connective tissue, often deposited in the perivascular, can invade heart, kidney, digestive tract, gallbladder, pancreas, liver, bronchus, lung, nervous system