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目的 :探讨米非司酮对胎盘功能的影响。方法 :对在我院病理性引产 16～ 19孕周的孕妇 13例 ,在服用 15 0m g米非司酮前后 2 4h各采集肘静脉血 5 ml,用放射免疫法检测血清 E2 、P、β- h CG、h PL水平。结果 :服用米非司酮后孕妇血清 P、β- h CG显著下降 (P<0 .0 1,P<0 .0 5 ) ,h PL有下降趋势 (P>0 .0 5 ) ,E2 无显著性变化 (P>0 .0 5 )。结论 :中孕妇女在使用米非司酮后胎盘分泌激素的功能受到影响。
Objective: To investigate the effect of mifepristone on placental function. Methods: Thirteen pregnant women with pathological induction of pathology in our hospital from 16 to 19 gestational weeks, 5 ml of elbow venous blood were collected before and after taking 150 mg mifepristone, and the serum levels of E2, P and β were measured by radioimmunoassay - h CG, h PL level. Results: The serum levels of P and β-h CG in pregnant women decreased significantly after taking mifepristone (P <0.01, P <0.05), h PL had a decreasing trend (P> 0.05) Significant changes (P> 0.05). CONCLUSIONS: The function of placental secretion of hormones is affected in mid-pregnant women after mifepristone administration.