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目的了解河南大学淮河医院药品不良反应(ADR)发生的特点,促进临床合理用药。方法对2007年1月—2009年12月收集到的224例ADR报告,分别从患者的性别、年龄、给药途径、药品类别、涉及器官或系统及主要临床表现等方面进行统计、分析。结果 224例ADR报告中,>60岁的患者ADR发生率最高(占34.82%);静脉给药方式是引发ADR的重要给药途径(占82.59%);最易引起ADR的药品为抗感染药;最常见的临床表现为皮肤及其附件损害。结论应加强合理用药监测工作,减少或避免ADR发生。
Objective To understand the characteristics of adverse drug reaction (ADR) in Huaihe Hospital of Henan University and to promote clinical rational use of drug. Methods A total of 224 ADR cases collected from January 2007 to December 2009 were collected and analyzed respectively according to their gender, age, route of administration, drug category, organ or system involved and major clinical manifestations. Results Among the 224 ADR cases, the incidence of ADR was the highest (34.82%) in patients> 60 years old. The intravenous route of administration was the most important route of ADR (82.59%); the drug most likely to cause ADR was anti-infective ; The most common clinical manifestations of damage to the skin and its accessories. Conclusion The rational drug use monitoring should be strengthened to reduce or avoid the occurrence of ADR.