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目的 探讨不同他汀类药物对术后认知功能障碍(POCD)的影响.方法 选择择期全麻手术患者240例,年龄50 ～ 80岁,ASA分级Ⅰ～Ⅲ级,根据是否服用他汀类调脂药物分为他汀组(n=120)和对照组(n=120).记录患者年龄、性别、文化程度、基础疾病、服用他汀类药物的种类和服药时程,同时记录患者术中丙泊酚及七氟烷等药物用量和生命体征的情况;记录患者术前1d,术后1、3、7d的简易精神状态量表(MMSE)的评分值,并记录发生POCD的例数.结果 两组患者的一般临床资料无显著差异(P＞0.05).术后1、3、7d时,他汀组MMSE评分均显著高于对照组(均P＜0.05),对照组和他汀组POCD发生率分别为22.2％ (26例)和14.4％(17例),21.3％ (25例)和5.9％(7例),10.3％(12例)和3.3％(4例),他汀组术后3d和7 d POCD发生率显著低于对照组(均P＜0.05).用药时间＞3个月的患者POCD发生率显著低于用药时间≤3个月的患者(5％ vs.22％,P＜0.05).结论 服用他汀类调脂药物可减少POCD发生率,且与术前服用药物时间有关.“,”AIM To investigate the effect of different statins on postoperative cognitive dysfunction (POCD) in patients with general anesthesia.METHODS A total of 240 patients,aged from 50 to 80 years,ASA Ⅰ ～Ⅲ grade,registered undergoing elective surgery with general anesthesia included in this study.Patients were divided into the statins group (n =120) and the control group (n =120) according to whether taking statins.The patients'age,sex,disease,the type and medication of taking statins time,the dosage of propofol or sevoflurane were recorded.The Mini Mental State Examination (MMSE) was conducted at preoperative 1 day and 1 day,3 day and 7 day after surgery and the number of POCD were recorded.RESULTS No statistical difference was found between two groups of general information (P ＞ 0.05).MMSE score in the statins group significantly higher than in the control group after surgery 1 day,3 day and 7 days (all P ＜ 0.05),and the incidence rate of POCD were 22.2％ (26) vs.14.4％ (17),21.3％ (25) vs.5.9％ (7),10.3％ (12) vs.3.3％ (4) in the control group and the statins group,respectively.The incidence rate of POCD in the statins group significantly lower than that in the control group after surgery 3 days and 7 days (both P ＜ 0.05).The incidence rate of whom have longer medication time (＞ 3 months) was lower than those who take statins less than three months (5％ vs.22％,P ＜ 0.05).CONCLUSION Statins medication can reduce the incidence of POCD,furthermore,which is relevant to the medication time of preoperative.