在发展中国家与发达国家,细菌性脑膜炎是引起严重疾病和死亡的常见病因,病死率在10%~50%,即使在医疗水平较高的国家,后遗症发生率仍然超过30%。同时细菌耐药性的增加使脑膜炎的治疗更加困难。在美国及其他已使用流感嗜血杆菌b型菌苗的国家,肺炎链球菌成为仅次于脑膜炎奈瑟球菌 Bacterial meningitis is a common cause of serious illness and death in developing and developed countries with a mortality rate of 10% to 50%. Even in countries with high medical standards, the incidence of sequelae still exceeds 30%. At the same time, increased bacterial resistance makes meningitis more difficult to treat. In the United States and other countries that have already used Haemophilus influenzae type b vaccine, S. pneumoniae became the second most common disease in Neisseria meningitidis