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严重创伤病人早期发生的凝血功能障碍称为创伤性凝血病(trauma induced coagulopathy,TIC)。其在急诊病人中发生率达38%,可加重出血,死亡率增加24%,是目前对重症创伤病人早期干预治疗的重点。新近研究表明,TIC是机体凝血和止血系统各部分功能的动态失衡所致,多种细胞因子和炎症介质参与创伤后凝血功能紊乱[1-3]。本研究重点探讨肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、白细胞介素6(interleukin-6,IL-6)和血小板活化因子(plateletactivating factor,PAF)与胸腹创伤凝血功能障碍关系,为重
Early onset of coagulopathy in severely traumatized patients is called trauma induced coagulopathy (TIC). Its incidence of emergency patients in 38%, can increase bleeding, the mortality rate increased by 24%, is currently the focus of early intervention in patients with severe trauma. Recent studies have shown that TIC is caused by the dynamic imbalance of the functions of various parts of the body’s coagulation and hemostasis systems. Many cytokines and inflammatory mediators are involved in post-traumatic coagulation disorders [1-3]. This study mainly focused on the effects of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and plateletactivating factor (PAF) Relationship, as heavy