肿瘤是严重危害人类生命健康的恶性疾病,肿瘤的发生、发展是一个多因子、多步骤的复杂生物学过程。从本质上讲,是调控细胞最基本活动的基因如癌基因、抑癌基因、凋亡相关基因等出现异常改变所致。Ｐ16基因是一种多肿瘤抑制基因,在多种癌症中都已检测到Ｐ16基因的异常表达。近年 Tumor is a malignant disease that seriously endangers human life and health. The development of tumor is a multifactorial and multi-step complex biological process. In essence, it is caused by the abnormal changes of genes that regulate the most basic activities of cells, such as oncogenes, tumor suppressor genes and apoptosis related genes. The P16 gene is a multi-tumor suppressor gene that has been detected in many cancers. in recent years