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许多研究已经表明,类阿斯匹林药物能减低催产药的作用,认为催产药通过PGs的合成对子宫的兴奋起到一定的作用。已知子宫蜕膜组织能产生几种PG,而子宫肌层几乎只合成PGI_2。用妊娠18～20天的大鼠子宫,取其肌层组织200mg,并将其悬浮在无钙的Krebs溶液中(25%,w/v),分别加入催产素(15mu/ml)。缓激肽(20μg/ml)和PGF_(2α)(1μg/ml),在20℃一起孵育15分钟后,吸出孵育液。以孵育液抑制ADP引起枸椽酸化的
Numerous studies have shown that aspirin-like drugs can reduce the effects of oxytocics and that oxytocin plays a role in uterine excitement through the synthesis of PGs. Uterine decidual tissue is known to produce several PGs, whereas the myometrium almost exclusively synthesizes PGI_2. The uterus of pregnant rats aged 18 to 20 days was harvested for 200 mg of muscular tissue and suspended in calcium-free Krebs solution (25%, w / v) and oxytocin (15 mu / ml) was added thereto. Bradykinin (20 [mu] g / ml) and PGF (2 [alpha]) (1 [mu] g / ml) were incubated together for 15 minutes at 20 [deg. Inhibition of ADP induced citrate formation by incubation solution