氧化／抗氧化失衡在慢性阻塞性肺疾病的发病中起重要作用,吸烟是引起氧化／抗氧化失衡的主要危险因素,一方面通过核转录因子κB(NF-κB)途径,引起具有伤害作用的促炎症介质基因表达增加,造成组织损伤;另一方面通过活化蛋白(AP-1)引起保护性抗氧化的γ-谷氨酰半胱氨酸合酶(γ-GCS)活化,它可以上调谷胱甘肽(GSH)的生成,增加机体的抗氧化能力。γ-GCS是决定GSH合成的限速酶。对γ-GCS的研究,尤其足对γ-GCS表达的调控已成为抗氧化研究的执点。 Oxidation / antioxidant imbalance plays an important role in the pathogenesis of chronic obstructive pulmonary disease. Smoking is a major risk factor for oxidative / anti-oxidative imbalance. On the one hand, the oxidative / antioxidant imbalance causes injury by the nuclear factor kappa B (NF-κB) pathway Increased proinflammatory gene expression results in tissue damage; on the other hand, activation of the protective antioxidant γ-glutamylcysteine ​​synthase (γ-GCS) by activated protein (AP-1) The formation of glutathione (GSH) increases the body’s antioxidant capacity. Gamma-GCS is the rate-limiting enzyme that determines GSH synthesis. Research on γ-GCS, especially regulation of γ-GCS expression, has become the focus of anti-oxidative research.