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目的了解梅州市接受HAART治疗的HIV/AIDS患者的CD4~+T细胞变化及影响因素,建立健全本地区HIV/AIDS患者CD4~+T淋巴细胞监测平台,为取得更好的治疗效果提供数据支持。方法调查并随访66例梅州市本地加入免费HAART治疗的HIV/AIDS患者,利用流式细胞术检测患者CD4~+T淋巴细胞水平,比较HAART治疗患者治疗前后CD4~+T数值的变化情况,进行统计学分析。结果经HAART治疗3个月以后,患者的CD4细胞有不同程度增高。同治疗基线CD4~+T细胞数目相比,治疗3、6、9、12和15个月后CD4~+T细胞平均数显著升高,分别增加110、128.9、143.2、108.4和190.8个(均为P<0.05)。治疗后,女性患者CD4~+T细胞平均数提高幅度大于男性。各年龄组CD4~+T细胞平均数升高趋势不同。结论接受HAART治疗可不同程度的提高HIV/AIDS患者CD4~+T细胞数目。CD4~+T细胞数目升高情况受性别、年龄和治疗时间影响。定期监测CD4~+T细胞计数的变化,有助于医生了解HIV/AIDS患者的病情发展和选择正确的治疗方案。
Objective To understand the changes of CD4 + T cells and the influencing factors of HIV / AIDS patients receiving HAART in Meizhou and to establish and improve the CD4 ~ + T lymphocyte monitoring platform of HIV / AIDS patients in this area to provide data support for better therapeutic effect . Methods Sixty-six HIV / AIDS patients were enrolled in free trial of HAART in Meizhou City. CD4 ~ + T lymphocyte levels were measured by flow cytometry. The changes of CD4 ~ + T values before and after treatment were compared with those of HAART patients Statistical analysis. Results After 3 months of treatment with HAART, CD4 cell count increased to some extent. Compared with the baseline number of CD4 ~ + T cells treated, the average number of CD4 ~ + T cells increased significantly at 3, 6, 9, 12 and 15 months after treatment (110,128.9,143.2,108.4 and 190.8, respectively) P <0.05). After treatment, the average increase in CD4 ~ + T cells in female patients was greater than that in men. The average increase trend of CD4 ~ + T cells in different age groups was different. Conclusions The treatment with HAART can increase the number of CD4 ~ + T cells in HIV / AIDS patients to varying degrees. CD4 ~ + T cell number increased by gender, age and treatment time. Regular monitoring of CD4 ~ + T cell counts will help physicians understand the progression of HIV / AIDS patients and select the right regimen.