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目的观察胃癌组织中HER2蛋白的表达变化,并探讨其临床意义。方法采用免疫组化法检测85例胃癌组织、癌周胃组织及正常胃组织中的HER2蛋白。结果 HER2蛋白在胃癌组织中、癌周胃组织及正常胃组织中的过表达率分别为23.5%、3.5%、0,前者明显高于后两者(P均<0.05)。HER蛋白过表达与胃癌的位置、Lauren分型、临床分期有关(P均<0.05)。结论胃癌组织中HER2蛋白过表达,检测HER2有助于胃癌的预后判断。
Objective To observe the expression of HER2 protein in gastric cancer and explore its clinical significance. Methods Immunohistochemistry was used to detect HER2 protein in 85 cases of gastric cancer tissues, gastric cancer tissues and normal gastric tissues. Results The over-expression rates of HER2 protein in gastric cancer tissues, gastric cancer tissues and normal gastric tissues were 23.5%, 3.5%, and 0, respectively. The former was significantly higher than the latter two (P < 0.05). The overexpression of HER protein was related to the location of gastric cancer, Lauren classification and clinical stage (P<0.05). Conclusion The over-expression of HER2 protein in gastric cancer tissues, and the detection of HER2 contributes to the prognosis of gastric cancer.