论文部分内容阅读
据报告 MNNC 是直接致癌物,它无须代谢激活,而能自发地分解形成烷化中间体,并生成阳碳离子,阳碳离子与 DNA 结合,可能导致癌变的发生.为了制备试管中细胞肿瘤模型,我们进行了用 MNNG 诱发金黄地鼠乳鼠肺细胞恶性转化实验。
It has been reported that MNNC is a direct carcinogen which can spontaneously decompose to form alkylated intermediates and generate cation carbon ions which bind to DNA and may cause carcinogenesis without metabolic activation.In order to prepare a cell tumor model in vitro , We performed MNNG induced malignant transformation of lung cells in golden hamster.