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目的研究卵巢上皮性肿瘤组织中人类软骨糖蛋白39(YKL-40)和癌胚抗原125(CA125)的表达,探讨其在卵巢恶性上皮性肿瘤进展中的作用机制及其临床意义。方法选取2000年3月至2004年5月在哈尔滨医科大学第一临床医学院手术标本,采用免疫组化两步法检测正常卵巢组织5例、卵巢良性肿瘤18例、卵巢交界性肿瘤14例和卵巢恶性上皮性肿瘤33例中YKL-40和CA125的表达。结果YKL-40和CA125表达水平随卵巢浆液性肿瘤恶性程度的增加而表达增高。YKL-40的表达与病理分级密切相关,但与临床分期无相关性,CA125与病理分级和临床分期均无关。结论检测YKL-40的表达可作为预测卵巢癌预后有价值的指标。
Objective To investigate the expression of human cartilage glycoprotein 39 (YKL-40) and carcinoembryonic antigen 125 (CA125) in ovarian epithelial neoplasm and to explore its possible mechanism and its clinical significance in the progression of ovarian malignant neoplasm. Methods From March 2000 to May 2004 in Harbin Medical University First Clinical Medical College surgical specimens, immunohistochemical two-step method to detect normal ovarian tissue in 5 cases, 18 cases of ovarian benign tumors, ovarian borderline tumors in 14 cases and Expression of YKL-40 and CA125 in 33 Cases with Malignant Epithelial Ovarian Tumors. Results The expression levels of YKL-40 and CA125 were increased with the increase of the malignant degree of ovarian serous tumors. The expression of YKL-40 is closely related to the pathological grade, but it has no correlation with clinical stage, and has no correlation with pathological grade and clinical stage. Conclusion Detection of YKL-40 expression can be used as a predictor of the prognosis of ovarian cancer.