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姜黄素(curcumin)是从中药姜黄(curucuma Longa L.)中提取的酚性物质,药理研究发现姜黄素具有免疫调节的作用,它能够调整T细胞、B细胞、巨噬细胞、自然杀伤细胞和树状突细胞的活性;还能够调整多种炎性细胞因子的表达及其介导的作用,包括肿瘤坏死因子、白介素-1、白介素-2、白介素-6等。目前已尝试将姜黄素用于阿耳茨海默氏病、哮喘、类风湿关节炎等与免疫异常相关的疾病。随着在细胞因子水平及分子水平对姜黄素免疫调节作用的进一步阐明,姜黄素对免疫系统疾病的治疗前景将十分光明。
Curcumin is a phenolic substance extracted from Curcuma Longa L. Curcumin has been found to have immunomodulatory effects and it can regulate T cells, B cells, macrophages, natural killer cells and The activity of dendritic cells; can also adjust the expression of a variety of inflammatory cytokines and its mediating effects, including tumor necrosis factor, interleukin-1, interleukin-2, interleukin-6 and so on. Attempts have been made to use curcumin for disorders related to immune disorders such as Alzheimer’s disease, asthma, and rheumatoid arthritis. With further elucidation of the immunoregulatory effects of curcumin at the cytokine level and at the molecular level, curcumin has a bright future for the treatment of immune system diseases.