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背景:动脉僵硬度是心血管疾病的独立危险因素。中心动脉反射波增强指数(augmentation index,AIx)是反映全身动脉僵硬度的重要指标。目的:研究新疆和田维吾尔族正常人群AIx,并进一步分析影响AIx的因素。方法:选取新疆和田地区559名维吾尔族正常人群(男251名,女308名),平均年龄(44.95±11.87)岁。所有研究对象均进行问卷调查、一般体格检查及血液生化检测,采用Sphygmocor脉搏波分析系统检测中心动脉收缩压及AIx。采用Pearson相关分析和偏相关分析进行两两相关分析,采用多元逐步回归分析AIx的影响因素。结果与结论:女性AIx值高于男性,且AIx与年龄呈正相关(男:r=0.548,女:r=0.405,P<0.05),在校正其他影响因素后,AIx与年龄仍呈正相关(男:r=0.182,女:r=0.234,P<0.05)。多元逐步回归显示中心动脉收缩压、收缩压、性别、年龄、C-反应蛋白是新疆维吾尔族AIx的影响因素。中心动脉收缩压、收缩压、年龄、体质量、C-反应蛋白是男性AIx的影响因素;中心动脉收缩压、收缩压、年龄、身高、C-反应蛋白是女性AIx的影响因素。说明在新疆维吾尔族正常人群中,AIx女性高于男性,且与年龄相关,中心动脉收缩压、收缩压和C-反应蛋白也是新疆维吾尔族人群AIx的影响因素。
Background: Arterial stiffness is an independent risk factor for cardiovascular disease. The augmentation index (AIx) is an important indicator of systemic arterial stiffness. Aims: To study AIx of Uygur normal population in Wada, Xinjiang and to further analyze the factors affecting AIx. Methods: A total of 559 Uighur normal subjects (251 males and 308 females) were selected in Hetian area, with an average age of 44.95 ± 11.87 years. All subjects were surveyed, general physical examination and blood biochemical tests using Sphygmocor pulse wave analysis system to detect central artery systolic blood pressure and AIx. Pearson correlation analysis and partial correlation analysis were used for any two correlation analysis, and multivariate stepwise regression analysis was used to analyze the influencing factors of AIx. RESULTS AND CONCLUSION: AIx was higher in women than in men, and AIx was positively correlated with age (r = 0.548, r = 0.405, P <0.05). After adjusting for other influencing factors, AIx was still positively correlated with age Male: r = 0.182, female: r = 0.234, P <0.05). Multiple stepwise regression showed that central artery systolic pressure, systolic blood pressure, gender, age, and C-reactive protein were the influencing factors of Uygur AIx in Xinjiang. Systolic blood pressure, systolic blood pressure, age, body weight and C-reactive protein were the influencing factors of male AIx. Central systolic blood pressure, systolic blood pressure, age, height and C-reactive protein were the influencing factors of female AIx. This indicates that among the normal Uygur population in Xinjiang, AIx women are higher than men and are related to age, central artery systolic pressure, systolic blood pressure and C-reactive protein are also the influencing factors of AIx in Xinjiang Uygur population.