动脉粥样硬化(As)已成为糖尿病患者的常见并发症和主要致死致残原因。持续的高血糖可使体内结构和功能蛋白质被糖基化修饰,形成有多种致 As 细胞生物学效应的糖基化终产物(AGEs),在人主动脉 As病灶中也检出 AGEs。As 和再狭窄的发生中血小板衍生生长因子(PDGF)表达异常,核苷酸序列分析证明人 sis 基因是 PDGF 的同源基因,表达的 PDGF 对调控血管平滑肌细胞(SMC)增殖起重要作用。我们已发现AGEs 有刺激大鼠主动脉 SMC 增殖的作用,现探讨 Atherosclerosis (As) has become a common complication of diabetic patients and the main cause of death and disability. Sustained hyperglycemia renders glycosylation of structural and functional proteins in the body to produce a variety of advanced glycation end products (AGEs) that are responsible for the biological effects of As cells and to detect AGEs in As lesions of the human aorta. As and restenosis, platelet-derived growth factor (PDGF) is abnormally expressed. Nucleotide sequence analysis shows that human sis gene is a homologous gene of PDGF. Expression of PDGF plays an important role in the regulation of proliferation of vascular smooth muscle cells (SMCs). We have found that AGEs stimulate the proliferation of aortic SMC in rats, is now explored