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骨关节病是一种生物性和机械性因素导致关节软骨发生退变的渐进性疾病，其病理发展的核心部分为关节软骨基质的破坏和关节软骨细胞的减少，并且累及软骨下骨、滑膜和关节囊等。Wnt信号通路不仅在人体发育以及维持成人组织稳态的过程中扮演重要角色，而且在关节形成、关节软骨发育及骨关节病的发生发展中均发挥重要作用，在关节病理学领域受到越来越多的关注。该文主要对骨关节病中Wnt信号通路及其与其他信号通路相互作用的研究进展做一简要综述。“,”Osteoarthropathy is a progressive disease that causes the degeneration of articular cartilage due to biological and mechanical factors. The destruction of the articular cartilage matrix and the reduction of articular cartilage cells are the core part of its pathological development, and subchondral bone, synovial membrane and joint capsule are also damaged. The Wnt signaling pathway not only plays an essential role in human development and the maintenance of adult tissue homeostasis, but also functions in the joint formation, articular cartilage development, and the occurrence and development of osteoarthropathy. It has become increasingly popular in joint pathology. In this paper, authors attempted to review the research progress of Wnt signaling pathway and its interaction with other signaling pathways in osteoarthropathy.