至今还没有一个成熟的男用口服避孕药可供广泛应用。鉴于甾体化合物仍存在某些不良反应,我们试图从非甾体化合物中寻找比较理想的避孕药。 1960年Caulston等发现双(二氯乙酰)二胺类化合物具有明显的抑制精子发生的作用,但在饮酒后可使服药者出现酒精中毒样反应。1972年Lesher报道了一系列双吡啶酰胺化合物用于女用 So far there is no mature male oral contraceptives for a wide range of applications. In view of steroid compounds still some adverse reactions, we have tried to find the ideal contraceptives from non-steroidal compounds. In 1960, Caulston et al. Found that bis (dichloroacetyl) diamines have obvious inhibitory effects on spermatogenesis, but alcoholic reactions may occur after taking alcohol. Lesher reported a series of bispyridine amide compounds for women in 1972