国际劳动卫生会议的重金属委员会于1971、1972和1974年举行了三次会议,讨论了镉、汞、铅的吸收、排泄、蓄积模型和剂量-反应关系等问题。本文重点综述其中有关镉的临界浓度和生物半减期计算方法问题。1.镉的代谢、临界器官和临界浓度日本成年人每日平均摄取和吸入60～80μg镉,其中4～7μg由肠道和肺吸收,体内含镉量约为35mg,肝和肾中各蓄积1/3左右,从尿排泄近吸收量的 Heavy Metal Commission of International Labor Conference held three meetings in 1971, 1972 and 1974 to discuss the absorption, excretion, accumulation model and dose-response relationship of cadmium, mercury and lead. This article focuses on the issue of how to calculate the critical concentration of cadmium and biological half-life reduction. 1. Metabolism of cadmium, critical organs and critical concentrations Japanese adults daily intake and inhalation of 60 ~ 80μg of cadmium, of which 4 ~ 7μg absorbed by the intestine and lungs, the body cadmium content of about 35mg, the accumulation of liver and kidney About 1/3, excreted from the urine absorption