论文部分内容阅读
目的探讨血清尿酸和血清胱抑素C(Cys-C)检测对评价II型糖尿病及合并肾功能损害的临床意义,并分析其与尿白蛋白排泄率(UAER)的关系。方法收集医院门诊和住院的II型糖尿病患者共253例,将II型糖尿病患者按其是否有肾脏损伤及损伤程度分为3组:单纯糖尿病组,糖尿病早期肾病组和糖尿病临床肾病组,并检测UAER、血清尿酸、Cys-C、血清肌酐(Scr)及尿肌酐,并计算内生肌酐清除率(Ccr)。结果血清尿酸和血清Cys-C随UAER的增加而增加,且差异有统计学意义(P<0.05),此外,各实验室指标性别间差异均有统计学意义(P<0.05);相关性分析结果显示,血清尿酸与UAER呈正相关(r=0.728,P<0.05),Cys-C与UAER也呈正相关(r=0.681,P<0.05)。结论在II型糖尿病肾病患者血清中,血清尿酸和Cys-C均呈现大幅升高的趋势。
Objective To investigate the clinical significance of serum uric acid and serum cystatin C (Cys-C) in the evaluation of type 2 diabetes mellitus and renal damage, and analyze its relationship with urinary albumin excretion rate (UAER). Methods Totally 253 outpatients and hospitalized patients with type II diabetes were collected. Patients with type 2 diabetes were divided into 3 groups according to whether they had kidney injury or not: simple diabetic group, early diabetic nephropathy group and diabetic nephropathy group. UAER, serum uric acid, Cys-C, serum creatinine (Scr) and urinary creatinine were calculated. Endogenous creatinine clearance (Ccr) was calculated. Results The levels of serum uric acid and serum Cys-C increased with the increase of UAER, and the difference was statistically significant (P <0.05). In addition, there were significant differences between the sexes in each laboratory index (P <0.05); The correlation analysis The results showed that there was a positive correlation between serum uric acid and UAER (r = 0.728, P <0.05) and Cys-C and UAER (r = 0.681, P <0.05). Conclusion Serum uric acid and Cys-C showed a significant increase in the serum of patients with type 2 diabetic nephropathy.