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叉头框蛋白p3(fork head box p3,Foxp3)是叉头样转录因子家族的成员之一,其主要表达于CD4+CD5+调节性T细胞(regulatory T cell,Treg),与该细胞的发育及生物学功能有密切的关系。Foxp3的表达与人类自身免疫系统疾病及多种类型肿瘤的发生、发展密切相关。现就Foxp3与CD4+CD5+Treg细胞关系及其在肿瘤转移中作用的研究进行综述。
Fork head box p3 (Foxp3) is a member of the forkhead-like transcription factor family and is mainly expressed on CD4 + CD5 + regulatory T cells (Tregs) Biological function is closely related. Foxp3 expression is closely related to the occurrence and development of human autoimmune system diseases and various types of tumors. Now Foxp3 and CD4 + CD5 + Treg cells and its role in tumor metastasis are reviewed.