论文部分内容阅读
目的:探讨早产儿羊水、脐血中IL-6、IL-8、TNF-α水平变化与支气管肺发育不良(BPD)的关系。方法:留取2010年1月～2012年6月分娩胎龄<34周的早产儿的羊水、脐血及胎膜,根据胎膜病理是否有绒毛膜羊膜炎(CAM),分为CAM组及非CAM组,检测羊水、脐血相关细胞因子,随访BPD发生率,回顾性分析相关细胞因子水平与BPD相关性。结果:CAM组的BPD发生率及胎膜早破发生率、早破时间与非CAM组比较,差异有统计学意义(P<0.05);CAM组BPD发生率明显高于非CAM组(P<0.05),CAM组羊水、脐血IL-6、IL-8水平明显高于非CAM组(P<0.05)。结论:检测羊水或脐血中IL-6、IL-8水平,对于BPD的早发现、早干预,降低严重并发症的发生率,有积极的临床意义。
Objective: To investigate the relationship between the levels of IL-6, IL-8 and TNF-α in amniotic fluid and umbilical cord blood of premature children and bronchopulmonary dysplasia (BPD). Methods: Amniotic fluid, umbilical cord blood and fetal membranes were collected from preterm infants of <34 weeks gestational age from January 2010 to June 2012. According to the presence or absence of chorioamnionitis (CAM) Non-CAM group, detection of amniotic fluid, umbilical cord blood related cytokines, follow-up BPD incidence, retrospective analysis of related cytokine levels and BPD correlation. Results: The incidence of BPD and the incidence of premature rupture of membranes, the time of premature rupture in CAM group were significantly different from those in non-CAM group (P <0.05). The incidence of BPD in CAM group was significantly higher than that of non-CAM group (P < 0.05). The levels of amniotic fluid and cord blood IL-6 and IL-8 in CAM group were significantly higher than those in non-CAM group (P <0.05). Conclusion: The detection of IL-6 and IL-8 levels in amniotic fluid or umbilical cord blood has positive clinical significance for the early detection and early intervention of BPD and the reduction of the incidence of serious complications.