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设计了一条合成氟比洛芬关键中间体(2-氟-4-联苯基)乙腈的新路线,选定了各步反应的较佳条件,获得较好收率,具有潜在的工业生产价值。
A new route for the synthesis of the key intermediate of flurbiprofen (2-fluoro-4-biphenylyl) acetonitrile was designed. The optimal conditions for each reaction step were selected to obtain better yields with potential industrial production value .