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目的:评价高危型人乳头瘤病毒(HR-HPV)检测联合液基薄层细胞学检查(TCT)在早期筛查宫颈病变中的价值。方法:对1 652例妇科门诊患者行TCT检查,对其中192例结果为低度鳞状上皮内病变(LSIL)、高度鳞状上皮内病变(HSIL)及部分结果为未明确诊断意义的不典型鳞状上皮细胞(ASCUS)、无上皮内病变或恶性细胞(NILM)的患者同时行HR-HPV检测及阴道镜下宫颈多点活检。结果:192例患者中宫颈活检阳性率为72.4%,LSIL和HSIL者宫颈活检阳性率显著高于NILM和ASCUS者。随着病理学诊断级别升高,HR-HPV阳性率也升高。HR-HPV阳性者宫颈活检的阳性率明显高于阴性者。结论:HR-HPV检测联合TCT筛查宫颈病变简单、有效。
Objective: To evaluate the value of high-risk human papilloma virus (HR-HPV) combined with liquid-based thin-layer cytology (TCT) in the early screening of cervical lesions. Methods: TCT was performed in 1 652 gynecological outpatients, including 192 cases of low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL) and some atypical cases with undetermined diagnosis Patients with squamous cell carcinoma (ASCUS), no intraepithelial lesion, or malignant cells (NILM) underwent both HR-HPV testing and colposcopic biopsy of the cervix. Results: The positive rate of cervical biopsy in 192 patients was 72.4%. The positive rate of cervical biopsy in LSIL and HSIL was significantly higher than those in NILM and ASCUS. With the rise of pathological diagnosis, HR-HPV positive rate also increased. HR-HPV-positive cervical biopsy was significantly higher than the negative rate. Conclusion: HR-HPV combined with TCT screening of cervical lesions is simple and effective.