已知无细胞百日咳疫苗 DTP( DTa P)的局部反应发生率和严重程度随剂次的递增而增加。目前已有少数儿童肌肉注射这种铝吸附疫苗后整个肢体肿胀的报道。但铝佐剂在局部反应原性中的确切作用尚不清楚。因此 ,本研究主要探讨美国儿童连续注射 4针和 5针 DTa P后铝盐含量与大面积肿? The incidence and severity of local reactions of acellular pertussis vaccine DTP (DTa P) are known to increase with increasing doses. A small number of children have been reported to have swollen the entire limb after intramuscular injection of this aluminum-adsorbed vaccine. However, the exact role of aluminum adjuvants in local reactivity is not clear. Therefore, the present study mainly explored the aluminum salt content and large area swelling of American children after continuous injection of 4-and 5-pin DTa P.