肿瘤坏死因子(TNF)是一具有细胞毒性活力和抗肿瘤多功能的细胞素,也是脓毒性休克中重要的介质。实验研究已提示霍乱毒素可以防止肿瘤负荷动物对TNF的致死作用而不改变其抗肿瘤效应。为了进一步探索涉及TNF作用的各种机理,选取C57B1/6雌鼠作实验,分两组,1)无肿瘤负荷:先作预试验,在分组49只鼠中确定所用的霍乱毒素剂量和与腹腔内注射大肠杆菌内毒素相隔的时间,所用重组 Tumor necrosis factor (TNF) is a cytotoxic and antitumor multifunctional cytokine that is also an important mediator of septic shock. Experimental studies have suggested that cholera toxin can prevent tumor-bearing animals from causing lethal effect on TNF without changing their anti-tumor effect. In order to further explore the mechanisms involved in the effects of TNF, C57B1 / 6 female rats were selected for the experiment and divided into two groups. 1) No tumor burden: A pretest was performed to determine the dose of cholera toxin used in the group of 49 rats, Intra-injection of E. coli endotoxin separated by the time of recombination