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目的探讨大肠癌患者血清中组织多肽抗原(TPS)的表达及在大肠癌病理中的变化特点。方法选取经病理证实的大肠癌患者60例,大肠良性病变患者40例,健康人血清(正常对照组)30例,空腹抽取静脉血检测TPS含量,并探讨与大肠癌生物学特性的相关性。结果大肠癌组血清TPS水平明显高于大肠良性病变组、正常对照组,差异有统计学意义(P<0.01)。大肠癌Ducks A期TPS水平明显低于B、C、D期,且淋巴结转移较为明显,差异有统计学意义(P<0.05)。结论 TPS在大肠癌患者血清中有较高的表达,且与大肠癌的分期,转移有较密切的联系。
Objective To investigate the expression of tissue polypeptide antigen (TPS) in the serum of patients with colorectal cancer and its changes in the pathology of colorectal cancer. Methods Totally 60 patients with colorectal cancer confirmed by pathology, 40 patients with benign colorectal lesions and 30 healthy individuals were enrolled in this study. TPS content was determined by fasting venous blood and the correlation with the biological characteristics of colorectal cancer. Results The serum level of TPS in colorectal cancer group was significantly higher than that in benign colorectal lesion group and normal control group (P <0.01). Colorectal cancer Ducks A phase TPS levels were significantly lower than B, C, D stage, and lymph node metastasis was more significant difference was statistically significant (P <0.05). Conclusion TPS is highly expressed in the serum of patients with colorectal cancer, and it is closely related to the staging and metastasis of colorectal cancer.