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经饮水对BALB/c~+小鼠给以去离子水配制的醋酸铅溶液(浓度为366 mg/L),染毒6个月,相当于每个动物每日摄入0.97±0.12mg的铅,对照组给予等量的去离子水。染毒期间,每月分別从实验组与对照组中各取5只动物,测定睾丸与血中的铅、睾丸酮及其合成途径中有关的甾类激素的水平(如4-雄烯二酮、17-羟孕酮、孕酮)。
The lead acetate solution (concentration of 366 mg / L) prepared by drinking water in BALB / c ~ + mice with deionized water for 6 months was equivalent to 0.97 ± 0.12 mg of lead per animal daily, The control group was given the same amount of deionized water. During the exposure period, five animals were taken from the experimental group and the control group separately. The levels of lead, testosterone and their related steroid hormones in testis and blood (such as 4-androstenedione, 17-hydroxyprogesterone, progesterone).