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由于急性粒细胞白血病(AML)能达到长期缓解,因此有中枢神经系统白血病(CNSL)复发的危险。作者复习了两组东部肿瘤协作组(ECOG)急非淋随机资料,就其中569例成人病例进行回顾性分析,探索对确定CNSL 有预后价值的危险因素。结果:569例 AML 中,CNSL 总发生率为5%(30/569),CR 期发生率为3%(10/331)。评价影响其发生率的各种因素(包括外周血白细胞数、血小板数、细胞组织学分型、CR期、年龄和性别)。资料表明,初期外周高白细胞数提示为 CNSL 的高危因素。外周血白细胞数>50000/μl 的病人一,并发CNSL 的危险性高达11%。Logistic 回归分析
Since acute myeloid leukemia (AML) can achieve long-term remission, there is a risk of recurrence of central nervous system leukemia (CNSL). The authors reviewed two groups of ECOG emergency non-lying data, and retrospectively analyzed 569 adult cases to explore the risk factors for determining the prognosis of CNSL. RESULTS: In 569 AML cases, the overall incidence of CNSL was 5% (30/569), and the CR rate was 3% (10/331). The factors affecting their incidence (including peripheral white blood cell count, platelet count, cell histological type, CR stage, age, and gender) were evaluated. The data show that the initial peripheral high leukocyte count suggests a high risk factor for CNSL. In patients with a peripheral blood leukocyte count of >50000/μl, the risk of concurrent CNSL was as high as 11%. Logistic regression analysis