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目的:探讨临床药师在经皮冠脉动脉介入治疗术(PCI)围术期患者使用抗血小板药物治疗方案中发挥的作用,以提高临床治疗效果,减少药品不良反应的发生。方法:依据最新的抗血小板药物诊治指南,结合相关文献分析1例PCI围手术期患者三联抗血小板药物治疗致急性上消化道出血的原因、用药的合理性及出血后的处理方案进行讨论,提出相关建议,以供临床参考。结果:为了保障临床安全、合理用药,对于高出血风险合并高血栓事件的人群应谨慎选择新型抗血小板药物,应优先选用抗缺血疗效好且出血风险低的药物。结论:临床药师积极参与临床合理用药,给予医师相关建议,以确保患者用药安全有效,在抗血小板药的合理应用中发挥积极作用。
Objective: To investigate the role of clinical pharmacists in antiplatelet therapy in perioperative patients undergoing percutaneous coronary intervention (PCI) to improve the clinical effect and reduce the incidence of adverse drug reactions. Methods: Based on the latest guidelines for the diagnosis and treatment of antiplatelet drugs and the related literatures, the causes of acute upper gastrointestinal hemorrhage caused by percutaneous antiplatelet drugs in one patient during perioperative period of PCI were analyzed. The rationality of the drugs and the treatment plan after bleeding were discussed. Relevant suggestions for clinical reference. Results: In order to ensure clinical safety and rational drug use, new antiplatelet drugs should be carefully selected for those patients with high bleeding risk and thrombosis. Drugs with good anti-ischemic efficacy and low risk of bleeding should be given priority. Conclusion: The clinical pharmacists actively participate in clinical rational use of drugs and give physicians recommendations to ensure that patients are safe and effective, and play an active role in the rational application of antiplatelet drugs.