2型糖尿病患者和甲状腺疾病患者血浆脂联素水平变化研究

来源 :中国地方病防治杂志 | 被引量 : 0次 | 上传用户:ohngahng
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
目的探讨2型糖尿病患者和甲状腺疾病患者血浆脂联素水平变化情况。方法选取本院2013年1月~2015年12月收治的70例2型糖尿病和70例甲状腺疾病患者作为本次研究对象,按照中国肥胖成年人标准,并根据患者体质量指数(BMI)将2型糖尿病患者分组为糖尿病肥胖组(BMI≥25kg/m~2)与糖尿病非肥胖组(BMI<25kg/m~2),分别为40例、30例;70例甲状腺疾病患者分为甲亢组(40例)和甲减组(30例),另选择同期来院健康体检的健康人群40例作为本次研究对照组,且BMI<25kg/m~2)。抽取患者空腹下静脉血液,并采用葡萄糖氧化酶法检测器血糖水平,采用电化学发光法检测其胰岛素水平;采用自动化学发光分析仪检测其FT3、FT4、TSH;采用酶联免疫吸附法检测其脂联素水平及血浆游离脂肪酸。结果甲亢患者脂联素水平为(11.9±6.7)ug/L明显高于其他组,差异具有统计学意义(P<0.05);糖尿病肥胖组患者脂联素水平为(4.7±1.9)ug/L明显低于糖尿病非肥胖患者组(7.1±3.7)ug/L、对照组(6.8±3.3)ug/L,差异具有统计学意义(P<0.05);然糖尿病非肥胖组与对照组比较,差异无统计学意义(P>0.05)。脂联素水平与总胆固醇(r=-0.30)、甘油三酯(r=-0.30)、BMI(r=-0.37)及低密度脂蛋白胆固醇(r=-0.24)、空腹胰岛素(r=-0.27)、空腹血糖(r=-0.27)、胰岛素抵抗(r=-0.23)呈负相关。在甲亢及甲减患者中,脂联素水平与FT4呈正相关(r=0.49,P<0.05);然与总胆固醇(r=-0.40)、低密度脂蛋白胆固醇(r=-0.36)呈负相关。于糖尿病及对照组中,脂联素水平与BMI(r=-0.37)、总胆固醇(r=-0.37)呈负相关。BMI是2型糖尿病和甲状腺疾病患者脂联素水平影响最为显著的因素;FT4为甲状腺疾病患者脂联素水平影响最为显著的因素。结论加强对2型糖尿病和甲状腺疾病患者肥胖程度的控制,同时做好甲状腺疾病患者FT4水平的检测,有利于患者临床疾病治疗和脂联素水平的控制,更好地改善其预后。 Objective To investigate the changes of plasma adiponectin level in patients with type 2 diabetes mellitus and thyroid diseases. Methods Seventy patients with type 2 diabetes mellitus and 70 thyroid diseases admitted to our hospital from January 2013 to December 2015 were enrolled in this study. According to the standard of Chinese obese adults and according to the body mass index (BMI), 2 Diabetic patients were divided into diabetic obesity group (BMI≥25kg / m ~ 2) and diabetes non-obese group (BMI <25kg / m2), 40 cases and 30 cases, respectively; 70 cases of thyroid disease were divided into hyperthyroidism group 40 cases) and hypothyroidism group (30 cases). Another 40 healthy subjects selected as healthy subjects during the same period as control group and BMI <25kg / m ~ 2. Fasting blood samples were collected from patients undergoing fasting blood glucose and blood glucose levels were measured by glucose oxidase method. The levels of insulin were detected by chemiluminescence assay. FT3, FT4 and TSH were detected by automated chemiluminescence analyzer. The enzyme-linked immunosorbent assay Adiponectin levels and plasma free fatty acids. Results The level of adiponectin in patients with hyperthyroidism was (11.9 ± 6.7) ug / L, which was significantly higher than that in other groups (P <0.05). The level of adiponectin in obese diabetic patients was (4.7 ± 1.9) ug / L (7.1 ± 3.7) ug / L in the non-obese diabetic group and 6.8 ± 3.3 ug / L in the control group (P <0.05). However, compared with the control group, the difference was statistically significant No statistical significance (P> 0.05). Adiponectin levels were positively correlated with total cholesterol (r = -0.30), triglyceride (r = -0.30), BMI (r = -0.37) and low density lipoprotein cholesterol (r = -0.24) 0.27), fasting blood glucose (r = -0.27) and insulin resistance (r = -0.23). In patients with hyperthyroidism and hypothyroidism, adiponectin levels were positively correlated with FT4 (r = 0.49, P <0.05), but negatively correlated with total cholesterol (r = -0.40) and low density lipoprotein cholesterol Related. In diabetes and controls, adiponectin levels were negatively correlated with BMI (r = -0.37) and total cholesterol (r = -0.37). BMI is the most significant factor affecting the level of adiponectin in patients with type 2 diabetes and thyroid disease; FT4 is the most significant factor affecting the level of adiponectin in patients with thyroid disease. Conclusions To strengthen the control of obesity in patients with type 2 diabetes mellitus and thyroid diseases and to detect the level of FT4 in patients with thyroid diseases, it is beneficial to the treatment of patients with clinical diseases and to the control of adiponectin levels to better improve their prognosis.
其他文献
目的探讨翻白草胶囊治疗糖尿病周围神经病变的患者的临床效果。方法将60例Ⅱ型糖尿病患者分为实验组和对照组,各30例。实验组服用翻白草胶囊,对照组服用安慰剂,治疗半年观察
随着纳米科技的兴起,"纳米尺度毛细作用学"确有充分理由成为纳米物理力学的新领域和新分支学科,应当大力发展,并简述这一领域的当前状况及展望.
采用脉冲喷射电沉积方法制备纳米晶镍镀层,利用X射线衍射(XRD)、透射电镜(TEM)和维氏硬度计对镍镀层微观结构及显微硬度进行了分析和表征,主要研究了峰值电流密度对镀层晶粒
目的 通过比较细菌培养、试管凝集试验(SAT)和虎红平板凝集实验(RBPT)对就诊患者的检测结果,探讨不同实验室方法对布鲁杆菌病的临床诊断效率,并通过诊后随访探讨疾病的演进过
三维N-S方程数值解表明尾迹型流动时-空发展由于展向非均匀性在下游产生旋涡位错.描述了它的基本特征与动力学过程.研究表明,旋涡位错是一个连续的涡旋动力学过程,它不是突然
目的探讨妊娠合并碘缺乏病的筛选对胎儿结局的影响。方法选择2008年4月~2014年5月潍坊市益都中心医院参加孕期保健的孕妇635例,对所有孕妇的临床资料做问卷调查分析,其中问卷
随着计算机技术的发展,微观化和计算机化是当今力学发展的两大趋势.从20世纪80年代开始,物理力学引入了包括分子动力学和蒙特卡罗法等计算机模拟的研究手段.本文简要介绍了量
目的 分析研究右旋美托咪定在碘缺乏型甲状腺肿大所致困难气道气管插管中的应用效果,为碘缺乏型甲状腺肿大所致困难气道患者的治疗提供新的麻醉方式及理论支持.方法 66例碘缺
我国的剖宫产率已经高达46.5%,明显高于其他亚洲国家的平均剖宫产率27.3%,而世界卫生组织颁布的合理剖宫产率仅为15%,而有关剖宫产及阴道分娩的优缺点,各学者的观点存在普遍
期刊
@@
桶形基础区别于桩基和普通浅基础的显著承载特性,就是垂直荷载的变化显著影响基础的水平承载力.提出了一种新的承载力简化计算方法,这种方法通过考虑垂直土反力承担抗倾覆弯
会议