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目的 :观察CPB复温期使用异丙酚对颈静脉血氧饱和度 (SjO2 )的影响.方法 :2 2例瓣膜置换术病人随机分为两组.异丙酚组 12例 (Ⅰ组 ) ,复温开始时至CPB结束 15分钟以异丙酚 4~ 6mg?kg-1?h-1持续静脉泵入 ;对照组 10例 (Ⅱ组 ) ,不用异丙酚.观察两组病人CPB前、CPB后 5分钟、低温稳定期、复温至鼻咽温 (NPT) 3 4℃及停CPB后 5分钟及 15分钟时SjO2 变化.结果 :异丙酚组复温至NPT3 4℃及停CPB后 5分钟时SjO2 显著高于对照组 (P“,”Objective: To observe the effect of propofol on jugular venous oxyhemoglobin saturation (SjO 2) duing rewarming period of cardiopulmonary bypass (CPB). Methods:22 patients undergoing heart valve replacement were allocated randomly into two groups. The patients in group Ⅰ propofol 4~6mg·kg -1 ·h -1 was infused continuously from the beginning of rewarming to 15 min after the end of CBP, while propofol was not used in group Ⅱ. The change of SjO 2 in two groups was observed at the follwing time points:before CBP, at 5 min after CBP, stable hypothermia stage, nasopharyngeal temperature (NPT) rewarmed to 34℃,5 min and 10 min after the end of CPB. Results: SjO 2 in group Ⅰ was higher significantly than that in group Ⅱ at NPT 34℃ and 5 min after the end of CPB (P<0 01,P<0 05). Cerebral oxygen extraction rate in group Ⅰ was lower significantly than that in group Ⅱ (P<0 01,P<0 05), although it was not lower significantly at NPT34℃ and 5 min after the end of CPB in group Ⅰ than that before CPB and after CPB. Conclusion:Propofol can prevent SjO 2 decrease during the rewarming period of CPB, thus it might have cerebral protection effect to some extent.