吡喹酮经皮肤给药治疗血吸虫病过去曾有过报道，但在剂型研究方面资料报道甚少，为此，我们进行了此项观察。1材料与方法1．1药物哈喳酮原药由南京制药厂提供，实验试剂均由市购。1．2动物NIH种小鼠，体重229－259，雌雄各半，由江苏省血防研究所实验动物室提供。日本血吸虫尾 Praziquantel transdermal delivery for the treatment of schistosomiasis has been reported in the past, but few reports on dosage form studies, for which we conducted this observation. 1 Materials and Methods 1.1 Drugs Hydrazone original drug provided by the Nanjing Pharmaceutical Factory, laboratory reagents are commercially available. 1.2 animals NIH species of mice, weighing 229-259, male and female, by the Jiangsu Provincial Institute of Anti-Laboratory Animal Laboratory provided. Schistosoma japonicum tail