论文部分内容阅读
本文对６９例胃癌、４２例大肠癌、３４例原发性肝癌中的内分泌型癌细胞进行了研究，运用免疫组织化学方法（ＰＡＰ法）检测了内分泌型癌细胞中的血清素、胃泌素、生长抑素，探讨了其病理及临床意义。结果显示：①内分泌型癌细胞阳性率在胃癌为３６．２３％（２５／６９），大肠癌为２８．５７％（１２／４２），在肝癌为１１．７６％（４／３４）；②激素产物分析显示：血清素最多见，胃泌素和生长抑素次之；肝癌内分泌型癌细胞所产生的激素为异位激素──胃泌素；③内分泌型癌细胞的阳性率在进展期胃癌、未分化胃癌高于早期胃癌和分化高的胃癌，淋巴结转移更常发生于内分泌型癌细胞阳性者。大肠癌和原发性肝癌中未发现这些关系。本文结果提示：这些特殊的内分泌细胞系由肿瘤干细胞分化而来，内分泌型癌细胞与胃癌的生物学行为有关，而并不影响大肠癌和原发性肝癌的生物学行为。
In this paper, endocrine cancer cells in 69 cases of gastric cancer, 42 cases of colorectal cancer, and 34 cases of primary liver cancer were studied. Serotonin and gastrin in endocrine cancer cells were detected by immunohistochemical method (PAP method). , Somatostatin, explored its pathological and clinical significance. The results showed that: 1 The positive rate of endocrine cancer cells was 36.23% (25/69) in gastric cancer, 28.57% (12/42) in colorectal cancer, and 11.76% (4/34) in liver cancer; 2 Hormone product analysis showed that serotonin was the most common, followed by gastrin and somatostatin; the hormone produced by endocrine cancer cells in liver cancer was the ectopic hormone-gastrin; 3 the positive rate of endocrine cancer cells was in the advanced phase. Gastric cancer and undifferentiated gastric cancer were higher than early gastric cancer and high-differentiated gastric cancer. Lymph node metastasis occurred more often in positive endocrine cancer cells. No relationship was found between colorectal cancer and primary liver cancer. The results of this study suggest that these special endocrine cell lines differentiated from cancer stem cells. Endocrine cancer cells are involved in the biological behavior of gastric cancer without affecting the biological behaviors of colorectal cancer and primary liver cancer.