α-硫辛酸(DDS)是1908年由Fromm.Witman合成的磺基制剂,也广泛地用于结核和疟疾。但自1947年Cochrane报告以来,主要作为抗麻风制剂,除此之外尚应用于皮肤科疾患。但是有各种副作用,其中最需注意的就是DDS综合征。DDS综合征是1951年由Allday等发现的,其特征是:①皮炎;②肝炎;③腺体增大,④单核细胞增多症等。他们指出应用DDS5～6周开始出现丘疹或脱屑样皮疹、发热及全身倦怠感等。不久,迅速出现肝 Alpha-lipoic acid (DDS) is a sulfo-based formulation synthesized by Fromm. Witman in 1908 and is also widely used in tuberculosis and malaria. However, since the Cochrane Report of 1947, it has been used mainly as anti-leprosy preparations, and in addition to dermatological disorders. But there are a variety of side effects, the most notable of which is DDS syndrome. DDS syndrome was discovered in 1951 by Allday, etc., characterized by: ① dermatitis; ② hepatitis; ③ gland enlargement, ④ mononucleosis syndrome. They point out that papules or desquamation-like rashes, fever and generalized burnout may occur beginning at 5-6 weeks of DDS. Soon, rapid liver appears