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一、前言Cefpodoxime Proxetil(CPDX-PR)为日本三井公司开发的口服头孢菌素类抗生素,系通过将抗菌活性优良但不能口服吸收的Cefpodoxime(CPDX)的4位羧酸形成异丙氧羰基氧乙基酯来提高口服吸收的药物。结构式如图1所示。
I. INTRODUCTION Cefpodoxime Proxetil (CPDX-PR) is an oral cephalosporin antibiotic developed by Mitsui of Japan and is formed from 4-carboxylic acid of Cefpodoxime (CPDX) which is excellent in antibacterial activity but can not be orally absorbed to form isopropoxycarbonyloxide B Esters to increase oral absorption of the drug. Structural formula shown in Figure 1.