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在英国布里斯托工作的Apley早在1958年就定义了反复性腹痛(RAP)。经过大量的研究,他发现8%的因RAP就诊于他的诊所的患儿存在器质性病变。本研究的目的是为了:①利用现代的方法学确定RAP的病因; ②找出与器质性RAP相关的因素;③确认那些非器质性的,但符合肠易激综合征(IBS)诊断标准的RAP患儿。该试验的研究对象为3岁以上的RAP患儿。这些患儿均完成了详细的问卷调查并进行了包括筛查试验在内的各种检查(腹腔血液筛查、幽门螺杆菌抗体浓度、炎症标志物、血清淀粉酶、肝功能检查、全血细胞计、大小便分析及腹部超声)。如果临床提示有必要,还会进行内窥镜检查和食道pH值监测。如果患儿没有器质性病变,同时又符合RomeⅡ标准则被诊断为IBS。在103例患儿中(中位年龄10岁,平均年龄10.04岁,s±3.44)
Apley, who worked in Bristol, England, defined recurrent abdominal pain (RAP) as early as 1958. After extensive research, he found that 8% of children with RAP who attended his clinic had organic disease. The purpose of this study was to: (1) identify the etiology of RAP using modern methodologies; (2) identify the factors associated with organic RAP; (3) identify those non-organic diagnoses that are consistent with irritable bowel syndrome (IBS) Standard RAP children. The study was designed for children over 3 years of age with RAP. All of these children completed a detailed questionnaire and performed various tests including screening tests (celiac blood screening, H. pylori antibody concentrations, inflammatory markers, serum amylase, liver function tests, whole blood counts , Urine analysis and abdominal ultrasound). If clinical tips warrant, endoscopy and esophageal pH monitoring are also performed. If there is no organic disease in children, while in line with the Rome Ⅱ standard was diagnosed with IBS. In 103 children (median age 10 years, mean age 10.04 years, s ± 3.44)