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目的 :调查本地区高危新生儿母婴弓形虫感染率 ,并通过治疗后随访了解其生命质量。方法 :采用ELISA方法同时检查 90例高危新生儿及其孕母血清循环抗原 (CAG)、特异性抗体IgM和 1gG。对阳性高危新生儿予以螺旋霉素治疗。治疗结束后复查血清循环抗原 (CAG)、特异性抗体LgM和LgG ,并于 3月、6月、2岁随访 ,常规体格检查、丹佛氏智测及眼底检查。结果 :高危新生儿组阳性率 6 6 7% ,正常新生儿组阳性率 1 76 % ,两者经统计学处理 ,明显 (x2 =4.17P <0 .5 )。高危新生儿其母组阳性率 3 36 % ,低于高危新生儿组。 6例阳性患儿治疗后复查Gag( - ) ,lgM( - ) ,lgG( +)。随访中 1例发生脑积水 ,余 5例未发现异常
Objective: To investigate the infection rates of Toxoplasma gondii in high-risk newborns in our region and to understand their quality of life after follow-up. Methods: Serum circulating antigen (CAG), IgM and IgM were detected in 90 high-risk infants and their pregnant mothers by ELISA. Spiramycin treatment of positive high-risk newborns. Serum circulating antigen (CAG), specific antibodies LgM and LgG were reexamined at the end of treatment, and were followed up in March, June, 2 years old, routine physical examination, Denver ’s mental examination and fundus examination. Results: The positive rate of high-risk neonates was 67.7%, while the positive rate of normal neonates was 76%. Both of them were statistically significant (x2 = 4.17P <0.5). High-risk neonatal mothers group positive rate of 36%, lower than the high-risk neonatal group. Six cases of positive children after treatment review Gag (-), lgM (-), lgG (+). Follow-up occurred in 1 case of hydrocephalus, and the remaining 5 cases found no abnormalities